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Test Code KITBM KIT Asp816Val Mutation Analysis, Qualitative PCR, Bone Marrow

Reporting Name

KIT Asp816Val Mutation Analysis, BM

Useful For

Diagnosing systemic mastocytosis

Method Name

Allele-Specific Oligonucleotide Polymerase Chain Reaction (PCR)
(PCR is utilized pursuant to a license agreement with Roche Molecular Systems, Inc.)

Performing Laboratory

Mayo Medical Laboratories in Rochester

Specimen Type

Bone Marrow

Specimen Required

The following information is required:

1. Pertinent clinical history

2. Clinical or morphologic suspicion

3. Date of collection

4. Specimen source


Specimen must arrive within 168 hours of collection.


Container/Tube: Bone marrow

Preferred: Lavender top (EDTA)

Acceptable: Yellow top (ACD solution B)

Specimen Volume: 2 mL

Collection Instructions:

1. Invert several times to mix bone marrow.

2. Send specimen in original tube.

3. Label specimen as bone marrow.

Forms: Hematopathology Patient Information Sheet (Supply T676) in Special Instructions

Specimen Minimum Volume

1 mL

Specimen Stability Information

Specimen Type Temperature Time
Bone Marrow Ambient (preferred) 7 days
  Refrigerated  7 days

Reject Due To


Mild OK; Gross reject







Reference Values

An interpretive report will be provided indicating the mutation status as positive or negative.

Day(s) and Time(s) Performed

Monday through Friday

CPT Code Information

81402-KIT (v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog) (eg, mastocytosis), common variants (eg, D816V, D816Y, D816F)

LOINC Code Information

Result ID Reporting Name LOINC Code
34852 Final Diagnosis: 34574-4

Test Classification

This test was developed and its performance characteristics determined by Mayo Clinic in a manner consistent with CLIA requirements. This test has not been cleared or approved by the U.S. Food and Drug Administration.